Fig. 1: Effects of 5-MeO-DMT on brain activity.
From: Vigilance state dissociation induced by 5-MeO-DMT in mice
The injection of 5-MeO-DMT transiently increased EEG slow wave activity and suppressed theta activity during wakefulness. a, b Representative 5 s raw EEG and EMG signal during wake, NREM sleep and REM sleep during baseline (a) or following an injection of 5 mg/kg 5-MeO-DMT (b). Epochs occurring 5–60 min after the injection. c Representative spectrogram of the 120 min following an injection of vehicle or 5-MeO-DMT in the frontal and occipital EEG derivation. EEG spectral analysis of the episodes of wake occurring between 0–30 min after the injections shown for the frontal (d) and occipital (e) EEG signals. d n = 8; Mixed-Effect (ME) analysis, effect of frequency*condition F152,1060 = 4.25, p < 0.0001, Fisher’s post hoc. e n = 8; ME analysis, effect of frequency*condition F152,908 = 14.15, p < 0.0001, Fisher’s post hoc). Mean + SEM. A black horizontal line denotes a significant difference between vehicle and 5-MeO-DMT at the corresponding frequency (Fisher’s LSD p < 0.05).
