Fig. 2: LFP slow wave analysis following an injection of 5-MeO-DMT.
From: Vigilance state dissociation induced by 5-MeO-DMT in mice
The injection of 5-MeO-DMT produced cortical LFP slow waves comparable to NREM sleep (a–d). Representative LFP traces with the corresponding neuronal spiking activity and EMG activity during baseline episodes of wake (a), NREM sleep (b) and REM sleep (c), or during wake in the 5–10 min following an injection of 5-MeO-DMT (d). e Average LFP slow wave (top) and corresponding multi-unit activity (bottom) in one representative animal during baseline NREM sleep, wake occurring 20 min after an injection of 5-MeO-DMT, and baseline wake (NREM sleep, n = 272; wake + 5-MeO-DMT, n = 505; wake (baseline) n = 119). Distribution of the amplitude (f) and duration (g) of LFP slow waves during NREM sleep and during waking after the injection of vehicle or 5-MeO-DMT. f n = 4; NREM*5-MeO-DMT: χ²55 = 8.50, p = 0.99; vehicle*5-MeO-DMT: χ²42 = 0.64, p < 0.001; NREM*vehicle: χ²42 = 92.11, p < 0.0001; g n = 4; NREM*5-MeO-DMT: χ²30 = 6.54, p > 0.99; vehicle*5-MeO-DMT: χ²30 = 1.80, p > 0.99; NREM*vehicle: χ²30 = 4.27, p > 0.99). Mean + SEM.
