Fig. 5: The effects of 5-MeO-DMT are partially mediated by 5-HT1A receptors.
From: Vigilance state dissociation induced by 5-MeO-DMT in mice
Spectral analysis of frontal (a) and occipital (b) EEG signals after an injection (a. n = 6; ME analysis, effect of frequency*condition: F234,1009 = 11.49, p < 0.0001, Fisher’s LSD p < 0.05; b n = 5; ME analysis, effect of frequency*condition: F234,651 = 13.31, p < 0.0001, Fisher’s LSD p < 0.05). Dynamics of EEG frontal (c) and occipital (d) delta (c. n = 6; ME analysis, effect of time point*condition: F84,196 = 2.37, p < 0.0001; Fisher’s LSD p < 0.05; d n = 5; ME analysis, effect of time point*condition: F78,116 = 2.01, p < 0.001; Fisher’s LSD p < 0.05). e Dynamics of occipital theta (n = 5; ME analysis, effect of time point*condition F87,143 = 2.92, p < 0.0001; Fisher’s LSD p > 0.05). f Pupil size dynamics (n = 5; ME analysis, effect of time point*condition F120,401 = 1.64, p < 0.001; Fisher’s LSD p > 0.05). g Correlation between delta cortical activity and pupil dilation (5-MeO-DMT + saline; Pearson’s simple linear regression, r² = 0.60, p < 0.05; 5-MeO-DMT + WAY; Pearson’s simple linear regression, r² = 0.01, p = 0.54). Horizontal line denotes a significant difference between: (from bottom to top) vehicle and vehicle+WAY (red); 5-MeO-DMT and vehicle (black); 5-MeO-DMT + WAY and vehicle (dark blue); 5-MeO-DMT + WAY and vehicle+WAY (light blue); and 5-MeO-DMT and 5-MeO-DMT + WAY (pink). Mean + SEM.
