Fig. 3: Role of P-body dynamics in cancer.
From: Reshaping cancer cell plasticity by P-body dynamics and protein translation
Under energy stress conditions, Trim23 ubiquitylates HAX1 that induces the binding between DDX6 and Lsm14A, favoring the assembly of P-bodies and colon rectal cancer growth. TGF-β promotes P-body assembly that positively correlates with breast cancer growth. cAMP induces the praja2-mediated ubiquitylation of DDX6 that stimulates P-body assembly and regulates glioblastoma. Phosphorylation of EDC3 by Pim1/3 kinases inhibits its localization at P-bodies, preventing their assembly and favoring the growth of prostate cancer. P-body disassembly causes protein translation of ADAR1 mRNA that, in turn, supports gastric cancer growth. Treatment with MEK inhibitors (MEKi) induces P-body dissolution and consequent translation of RAS mRNA that supports chemoresistance.
