Fig. 1: MeDIP-seq reveals genome-wide methylation profiles in SCLC. | Communications Biology

Fig. 1: MeDIP-seq reveals genome-wide methylation profiles in SCLC.

From: Integrated methylome analysis identifies an epigenetically silenced tumor suppressor RASA4 in small cell lung cancer

Fig. 1: MeDIP-seq reveals genome-wide methylation profiles in SCLC.

A Volcano plot of DMRs across the whole genome in plasma cfDNA between pre-treatment and progression from ES-SCLC patients (left panel). Volcano plot of the DMRs across the whole genome in tissue DNA between tumors and adjacent normal tissues from LS-SCLC patients (right panel). B Distribution of the DMRs on chromosomes. The red areas represent the hypermethylated regions, and the blue areas represent the hypomethylated regions. C The distribution of genomic locations for the DMRs. D Volcano plot of DMRs within the promoter regions in plasma cfDNA between pre-treatment and progression from ES-SCLC patients (left panel). Volcano plot of the DMRs within the promoter regions in tissue DNA between tumors and adjacent normal tissues from LS-SCLC patients (right pannel). E GO and KEGG analysis of genes associated with the DMRs within the promoter regions in tissue DNA. F GO and KEGG analysis of genes associated with the DMRs within the promoter regions in cfDNA.

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