Fig. 2: Identification of frequent methylation in the promoter region of RASA4 in SCLC. | Communications Biology

Fig. 2: Identification of frequent methylation in the promoter region of RASA4 in SCLC.

From: Integrated methylome analysis identifies an epigenetically silenced tumor suppressor RASA4 in small cell lung cancer

Fig. 2: Identification of frequent methylation in the promoter region of RASA4 in SCLC.

A The workflow of the integrated analysis of MeDIP-seq data of plasma cfDNA and tissue DNA. B KEGG analysis of genes associated with the 154 shared DMRs. C Methylation peaks of the DMR (Chr7: 102254100-102244400) within the RASA4 promoter in plasma cfDNA and tissue DNA, as determined by MeDIP-seq. D The DMR (Chr7: 102,254,100-102,244,400) contains binding sites for transcription factors TFAP2A and RUNX1, predicted in the JASPAR database. E BSP analysis of the CpG sites in the DMR (Chr7: 102254100-102244400) within the RASA4 promoter in 10 paired SCLC tumor and adjacent normal tissues. The data are shown as mean ± SD from 10 SCLC patients (n = 10, paired Student’s t-test).

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