Fig. 6: HOXA2 overexpression relieves kidney dysfunction and renal collagen deposition in UUO mice. | Communications Biology

Fig. 6: HOXA2 overexpression relieves kidney dysfunction and renal collagen deposition in UUO mice.

From: HOXA2 exerts anti-renal fibrosis effects through reducing endoplasmic reticulum stress via the upregulation of SIRT1

Fig. 6

A Schematic of the mouse experimental protocol including AAV-HOXA2 (+) treatment and UUO model establishment. B Serum creatinine and (C) Serum BUN in each group at 12 weeks of age. D Representative images of H&E, Masson’s trichrome and picro-sirius red stainings and relative tubular injury score and relative collagen deposition area of each group (×200). Bar = 100 μm. Data are presented as the mean ± SD of each mouse (n = 6 mice in each group). **P < 0.01, NS not significant.

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