Fig. 2: Nutrient overload induces insulin resistance.
From: A microphysiological model of human MASLD reveals paradoxical response to resmetirom
A Glucose output is significantly increased in both Condition 1 + FFA and Condition 2 over the baseline condition on days 12 and day 19. ### p < 0.001 for the dose variable, and * p < 0.05, ** p < 0.01, *** p < 0.001 via two-way ANOVA. B Condition 2 has impaired PCK1 responsiveness to insulin at 0.1 and 10 nM compared with Condition 1. G6PC expression is similar across all doses and sample sets. * p < 0.05, ** p < 0.01 *** p < 0.001 via two-way ANOVA. C Insulin uptake is significantly different between Condition 2 and all other conditions at 9 and 16 days incubation. All data acquired from male SMC donor. Two-way ANOVA; * p < 0.05, *** p < 0.001. n = 4; all samples.
