Fig. 3: Visually evoked 5-Hz oscillations in V1 and their dynamic changes following treatment with 5-HT2AR agonist.
a Trial averaged V1 population membrane voltage activity (shading represents SEM) before (i-ii) and after (iii-iv) treatment of the 5-HT2AR agonist (TCB2 in this example). b Time-resolved spectral analysis of the evoked oscillations shown in a-i. Time zero indicates onset of visual stimulus. c Same as b after drug treatment (a-iii), showing an increase in both duration and amplitude of 5-Hz oscillations. d Duration of oscillations before and after treatment comparing the mean across all experiments (indicated inside, *p-value = 0.0144, paired t test) and individual trials (indicated outside, ***p-value = 1.35e-06, Welch’s t-test, nbefore = 109 and nafter = 189). Data based upon N = 7 experiments in 5 mice, symbol shape indicates individual mouse experiments. e Same as d, for mean oscillatory power across all experiments (indicated inside, *p-value = 0.016, paired t test) and individual trials (indicated outside, ***p-value = 5.91e-04, Welch’s t-test).
