Fig. 6: Prolonged light exposure alters neuronal architecture. | Communications Biology

Fig. 6: Prolonged light exposure alters neuronal architecture.

From: Prolonged visual experience accelerates developmental synaptic downscaling via epigenetic regulation and Rab5c mediated AMPA receptor trafficking

Fig. 6: Prolonged light exposure alters neuronal architecture.The alternative text for this image may have been generated using AI.

a, b Illustrative examples of complete dendritic arbor reconstructions from time-lapse imaging of control (Ctrl-GFP), Rab5c-overexpressing (Rab5c-GFP), and Rab5c knockdown (Rab5c-MO) tectal neurons in 12LE and 20LE tadpoles. Upper panels: raw confocal microscopy images; lower panels: 3D reconstructions using Imaris. Arrowheads indicate axons. c–e Quantitative analysis of total dendritic branch length (TDBL), branch tip number (TBTN), and dendritic area. 12LE: n = 7, 7, 8; 20LE: n = 8, 11, 7 for Ctrl-GFP, Rab5c-GFP and Rab5c-MO + Ctrl-GFP. *p < 0.05, **p < 0.01, ***p < 0.001 (two-way ANOVA with post hoc Tukey’s HSD test).

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