Fig. 3: haCCA performs consistent integration of 10X Visium and MALDI-MSI spatial data.
From: haCCA: multi-module Integration of spot-based spatial transcriptomes and metabolomes
A Integration performance on same-section data from three mouse brain specimens. For each specimen, panels show metabolic clusters from MALDI-MSI (left), transcript clusters from 10X Visium (middle-left), and metabolic cluster distribution after integration using STUtility (middle-right) and \({haCCA}\) (right). \({haCCA}\) maintains consistent spatial patterns. B Integration performance on neighboring-section data. C Spatial distribution patterns of dopamine are shown in MALDI-MSI(left) and \(h{aCCA}\) integrated data (middle), alongside the expression pattern of tyrosine hydroxylase (Th) from spatial transcriptomics(right). Indicated that \({haCCA}\) integration (middle panels) successfully preserves the spatial correspondence between metabolites and their associated genes.
