Fig. 3: Transcriptomic signature reveals a distinct profile of agl-1 mutants. | Communications Biology

Fig. 3: Transcriptomic signature reveals a distinct profile of agl-1 mutants.

From: CHK1 inhibition rescues abnormal glycogen buildup in a Caenorhabditis elegans model for glycogen storage disease III

Fig. 3: Transcriptomic signature reveals a distinct profile of agl-1 mutants.

A Fold change analysis shows a higher number of downregulated genes in wild-type compared to mutants (Δagl-1, W1044X, and S1444R); p < 0.05. B Volcano plot shows that MSRB1/2 genes are significantly downregulated, whereas SMPD1 and EPHX1 are significantly up-regulated; p < 0.05. C Heat map shows clustering of the 20 most differentially expressed genes in W1044X, S1444R, and Δagl-1 mutants compared to wild-type; p < 0.05. D Pathway enrichment analysis of combined mutants shows significantly activated and suppressed pathways in GSDIII C. elegans models based on GeneRatio score (Δagl-1, W1044X, and S1444R). E. Interaction analysis of combined mutants suggests interplay between the identified pathways. Data are presented as mean ± SEM.

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