Table 4 Regulatory effect of arbaclofen in autistic participants

From: Differential GABA dynamics across brain functional networks in autism

Theta-beta PAC

Autism_P vs. Control_P

Autism_L vs. Control_P

Autism_H vs. Control_P

t(30)

p

t(33)

p

t(30)

p

FPN

3.

0.007

2.2

0.05

2.8

0.01

DMN

3.7

0.003

2.6

0.025

2.9

0.01

DAN

1.1

0.27

1.8

0.1

0.06

0.9

VAN

2.6

0.01

2.6

0.025

2

0.05

SMNa

3.2

0.005

4.4

0.001

1.2

0.2

VNa

4.4

0.001

2.6

0.025

1.8

0.1

Limbic Network

Autism_P vs. Control_P

Autism_L vs. Control_P

Autism_H vs. Control_P

t(30)

p

t(33)

p

t(30)

p

Theta-beta PAC

4

0.0015

1.8

0.1

3.1

0.01

Alpha-beta PAC

2.9

0.0075

1.4

0.19

1.7

0.12

Theta-gamma PAC

3.3

0.004

2.4

0.06

2.9

0.01

Alpha-gamma PAC

3.3

0.004

1.1

0.3

3.1

0.01

  1. aNetworks exhibiting significant group differences under placebo conditions, with these differences reversed subsequent to the administration of high-dose arbaclofen in the autism group. Bolded parts indicate situations with significant group differences. Reported p-values have been corrected for multiple comparisons.
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