Fig. 4: PiR48444 antagomir protects LPS-induced and aging-related trabecular bone loss. | Communications Biology

Fig. 4: PiR48444 antagomir protects LPS-induced and aging-related trabecular bone loss.

From: PiR48444 inhibits MSC osteogenic differentiation and bone regeneration via targeting METTL7A/eIF4E-mediated BMP2 m6A methylation

Fig. 4: PiR48444 antagomir protects LPS-induced and aging-related trabecular bone loss.The alternative text for this image may have been generated using AI.

A HE staining in LPS-treated male and female mice. B Representative micro-CT images for trabecular bone in LPS-treated male and female mice. C Bone mineral density (BMD), bone volume/total volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) in LPS-treated male mice and female mice (n = 8). D HE staining in 18-month-old male and female mice. E Representative micro-CT images for trabecular bone in 18-month-old male mice and female mice (n = 6). F Bone mineral density (BMD), bone volume/total volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) in male mice and female mice (n = 6). Data are presented as mean ± SD (C, F). Statistical significance was determined by one-way ANOVA (C) and Student’s t test (F). Significance levels: *p < 0.05 and **p < 0.01, and ***p < 0.001.

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