Fig. 4: Hub genes and transcriptional regulation of T cell function in GDM. | Communications Biology

Fig. 4: Hub genes and transcriptional regulation of T cell function in GDM.

From: Single-cell and proteomic profiling unveil aberrant immune phenotypes in gestational diabetes following assisted reproductive technology

Fig. 4: Hub genes and transcriptional regulation of T cell function in GDM.

A Protein-protein interaction (PPI) networks of upregulated differentially expressed genes (DEGs) in each T cell subtype in the GDM group. B Top 10 hub genes among upregulated DEGs in each T cell subtype in the GDM group. C Differential transcription factor (TF) activity and specificity scores in CD8⁺ T cells between the GDM and NP groups. D Differential TF activity and specificity scores in CD4⁺ T cells between the GDM and NP groups. E TF-regulated intergroup differential genes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment in CD8+ T cells. F TF-regulated intergroup differential genes and KEGG pathway enrichment in CD4+ T cells.

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