Fig. 7: Characterization of B cell immune repertoires in women with GDM undergoing ART treatment. | Communications Biology

Fig. 7: Characterization of B cell immune repertoires in women with GDM undergoing ART treatment.

From: Single-cell and proteomic profiling unveil aberrant immune phenotypes in gestational diabetes following assisted reproductive technology

Fig. 7: Characterization of B cell immune repertoires in women with GDM undergoing ART treatment.

A Uniform manifold approximation and projection (UMAP) plot of αβ B cell receptor (BCR)-matched B cells. B Bar plot illustrating the distribution of BCRs across distinct B cell subtypes. C Dot plot showing BCR clonal expansion across distinct B cell subtypes. D Volcano plot illustrating differentially expressed genes (DEGs) in expanded B cells between the GDM and NP groups. Genes with |log2(FC)| ≥0.25 and adjusted p < 0.05 are labeled with their respective gene symbols. E Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of intergroup DEGs in expanded B cells. F Clonal abundance and diversity of BCR between the GDM and NP groups. G U Usage preferences of immunoglobulin heavy chain variable (IGHV) genes and immunoglobulin heavy chain joining (IGHJ) genes in the GDM group. p values are calculated using the Wilcoxon rank-sum test. A red asterisk indicates a statistically significant difference between the GDM group and NP group. H Bar plot showing the top 10 immunoglobulin heavy chain complementarity-determining region 3 (IGH CDR3) amino acid sequences (AA) sequences in the GDM and NP groups.

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