Fig. 2: Distribution of backbone RMSD of the HCN2 CNBD and C-linker structural domains. | Communications Biology

Fig. 2: Distribution of backbone RMSD of the HCN2 CNBD and C-linker structural domains.

From: An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channel

Fig. 2: Distribution of backbone RMSD of the HCN2 CNBD and C-linker structural domains.

Panel a shows the systems bound to cGMP while panel b shows those bound to cAMP. Different colors identify different subunits. No ligands are bound in the systems with 0 cGMP/cAMP; in 1 cGMP/cAMP complexes, one ligand is bound to subunit one; in 2 syn cGMP/cAMPs, a ligand is bound to both subunits one and two; in 2 trans cGMP/cAMPs, a ligand is bound to subunit one and three, respectively; in 3 cGMP/cAMPs, a ligand is bound to subunits one, two and three, respectively; in 4 cGMP/cAMPs, each subunit is bound by one ligand. The x-axis shows different regions corresponding to Fig. 1b. Values correspond to the mean over the four independent replicas ± standard deviation.

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