Fig. 6: Potential mechanisms for MYC2 modulation of TOC1 occupancy at target defence gene promoters. | Communications Biology

Fig. 6: Potential mechanisms for MYC2 modulation of TOC1 occupancy at target defence gene promoters.

From: The core clock transcription factor TOC1 binds directly to defence gene promoters regulating immunity in Arabidopsis

Fig. 6: Potential mechanisms for MYC2 modulation of TOC1 occupancy at target defence gene promoters.The alternative text for this image may have been generated using AI.

In uninfected plants, MYC2 is kept in an inactive state by the JAZ repressor complex. A TOC1 is recruited to the G-box (orange) by direct interaction with inactive MYC2, repressing defence gene expression. Detection of B. cinerea leads to COI1-mediated degradation of JAZ repressors. MYC2 undergoes a conformational change, releasing TOC1 and abolishing TOC1-mediated repression. B Inactive MYC2 promotes direct binding of TOC1 to the G-box. Active MYC2 displaces TOC1 from the G-box or recruits co-activators (X) which block TOC1 binding.

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