Table 1 In vitro bioactivity of insulin penicillamine analogs
From: Synthesis of disulfide-rich heterodimeric peptides through an auxiliary N, N-crosslink
Insulin penicillamine analog | EC50 (nM) | Relative potency (%) |
|---|---|---|
Human insulin | 0.5 | 100.0 |
A20 | 4.6 | 11.0 |
B19 | 17.7 | 3.0 |
B7 | 20.0a | 2.5a |
A7 | 740.0 | 0.1 |
A6 | 4.9 | 10.0 |
A11 | 760.0 | 0.1 |
