Fig. 6
From: Copper/iron co-catalyzed alkoxycarbonylation of unactivated alkyl bromides
Substrate scope for the alkoxycarbonylation of unactivated alkyl bromides. a Reaction studied, with the structure of L8 inset; b Table of substrates. All yields are isolated yields except mentioned. The gray circles highlight the position of bromide. Reaction conditions: 2-bromotetradecane (0.5 mmol), CuTc (5 mol%), L (5 mol%), Fe3(CO)12 (5 mol%), NaOMe (0.75 mmol), CO (40 bar), MeOH/toluene (0.5/2 mL), 24 h. *GC yields. ‡2-bromotetradecane (0.5 mmol), CuTc (5 mol%), L (5 mol%), Fe3(CO)12 (5 mol%), NaOMe (1.5 mmol), CO (40 bar), alcohol (20 eq.), toluene (2 mL), 24 h. §NaOtBu instead of NaOMe
