Table 4 In vitro activities of 22 against liver stage P. berghei and cytotoxicities (luciferase-expressing P. berghei ANKA GFP-Luc-SMcon sporozoites; data ± SD from biological duplicate (n = 2) and technical quadruplicate measurements)

From: Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites

Compound

IC50 (nM)

Maximum inhibition %

HepG2 IC50 (μM)

Artemether

>104

49.4

ND

Atovaquone

0.616 ± 0.014

80.4

>0.250 ± 0

Puromycin

48.55 ± 0.071

92.6

0.138 ± 0.018

22

0.316 ± 0.020

104

>50.0 ± 0

Back to article page