Table 1 In vitro potencies of RXR modulating natural products
Natural product | EC50 RXRα | EC50 RXRβ | EC50 RXRγ |
|---|---|---|---|
Drupanin (1)17 | 2.1 ± 0.1 µM | 4.6 ± 0.3 µM | 7.0 ± 0.3 µM |
Honokiol (2)18 | 11.8 µM | — | — |
Bigelovin (3)19 | 4.9 µM | — | — |
Valerenic acid (4)4 | 27 ± 3 µM | 5.2 ± 0.4 µM | 43 ± 1 µM |
Isopimaric acid (5)4 | 26 ± 1 µM | 32 ± 1 µM | 33 ± 1 µM |
Dehydroabietic acid (6)4 | 42 ± 3 µM | 42 ± 1 µM | 42 ± 1 µM |
