Table 2 In vitro activity of designs 7–10 on RXRs

From: Tuning artificial intelligence on the de novo design of natural-product-inspired retinoid X receptor modulators

ID

EC50 (fold activation)

RXRα

RXRβ

RXRγ

7

Inactive at 50 µM

Inactive at 50 µM

Inactive at 50 µM

8

Inactive at 50 µM

Inactive at 50 µM

Inactive at 50 µM

9

29 ± 5 µM (10 ± 1)

27 ± 1 µM (11 ± 1)

19.1 ± 0.1 µM (6.1 ± 0.1)

10

16.9 ± 0.6 µM (66 ± 4)

15.7 ± 0.8 µM (59 ± 5)

>50 µM

  1. Data represents mean ± SEM of at least two independent experiments in duplicates.
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