Fig. 1 | Communications Chemistry

Fig. 1

From: Biocatalytic methylation and demethylation via a shuttle catalysis concept involving corrinoid proteins

Fig. 1

Conventional procedures for O-methylation and -demethylation. a Toxic methyl iodide (MeI) or dimethylsulfide (DMS) are commonly used methylating agents under basic conditions. Alternatives are dimethylcarbonate (DCM) or methanol (MeOH), which however require an elevated temperature. b Strong Bronsted- or Lewis acids such as hydrobromic acid (HBr) or boron tribromide (BBr3), respectively, as well as sodium ethanethiolate (NaSEt) are the traditional reagents for demethylation

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