Fig. 5 | Communications Chemistry

Fig. 5

From: Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model

Fig. 5

Progressive inhibition of cholinesterases (ChEs) by 11 and X-ray crystal structures of ChEs after incubation with 11. a Progressive inhibition of huAChE and b huBuChE by 11. Values are mean ± SEM. c Close-up view of the active-site in the the X-ray structure of TcAChE (PDB ID 6EUE; resolution 2.05 Å) and d huBuChECHO (PDB ID 6EYF; resolution 2.60 Å) after incubation with 11, showing carbamylated Ser200 and Ser198 residues, respectively. Carbon atoms are, respectively, represented in yellow in TcAChE and green in huBuChE. The carbamyl moiety is in grey, oxygen atoms in red, and nitrogen atoms in blue. The Fo − Fc electron density maps calculated by omitting carbamylated Ser200 in TcAChE or carbamylated Ser198 and molecule 11 in huBuChE from the respective models are represented as grey mesh with a 3.0 σ contour

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