Fig. 2 | Communications Chemistry

Fig. 2

From: Lewis base-catalyzed intermolecular triazene alkyne cycloaddition for late-stage functionalization and scaffold diversification

Fig. 2

Scope of terminal and internal alkynes. a Reaction scheme. b Terminal alkynes. c Internal alkynes. Reaction conditions: alkynes 1 or 4 (0.3 mmol, 1.0 equiv.) and CF3CHN2 2 (1.2 mmol, 4 equiv., 1.5 M in toluene), DBU (0.06 mmol, 20 mol%), 1,4-dioxane (0.4 mL), 80 °C, 12–32 h; yields of isolated products 3 or 5 after chromatography

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