Fig. 3 | Communications Chemistry

Fig. 3

From: Lewis base-catalyzed intermolecular triazene alkyne cycloaddition for late-stage functionalization and scaffold diversification

Fig. 3

Late-stage functionalization. a Reaction scheme. b Late-stage functionalization of marketed drugs. Reaction conditions: 6 (0.3 mmol, 1.0 equiv.) and CF3CHN2 2 (1.2 mmol, 4 equiv., 1.5 M in toluene), DBU (0.06 mmol, 20 mol%), 1,4-dioxane (0.4 mL), 80 °C, 24-30 h; yields of isolated products 7 after chromatography

Back to article page