Fig. 6 | Communications Chemistry

Fig. 6

From: Lewis base-catalyzed intermolecular triazene alkyne cycloaddition for late-stage functionalization and scaffold diversification

Fig. 6

Application of TAC strategy for drug-like molecule development. a Envisaged TAC method for the synthesis of antiplatelet drug-like molecules. b Synthesis of target molecules 10a–c. c Stereo diagram of binding conformation of novel analogs 10a–c with COX-1 isozyme (PDB:3N8Y). d The Platelet aggregation inhibition assay (error bars means ± standard deviation from three independent experiments)

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