Table 2 Displacement of [3H]rosiglitazone by sulfonamide compounds with recombinant human mitoNEET

From: Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand

Compounds

IC50 (μM) ±std error

clogPa

Furosemide

29.26 ± 0.97

1.90

1

1021.00 ± 0.96

1.11

2a

81.43 ± 0.92

2.33

2b

42.56 ± 1.03

2.86

2c

54.26 ± 0.92

3.39

2d

9.12 ± 1.04

3.92

2e

19.82 ± 0.90

4.45

2f

6.24 ± 0.88

4.98

2k

31.16 ± 1.02

3.31

2l

20.79 ± 1.01

2.72

2n

8.82 ± 1.00

2.87

2p

12.38 ± 1.23

2.37

Arachidonic acid

2.93 ± 1.06

6.3

  1. aCalculate using Chemdraw 16.0.1.4
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