Fig. 1 | Communications Chemistry

Fig. 1

From: The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis

Fig. 1

Histone lysine methyltransferase-catalyzed methylation of lysine. a Methylation of lysine residue by histone lysine methyltransferases using SAM as a methyl donor. b View on the crystal structure of SETD8 with H4K20 peptide (magenta) and SAH (yellow). c View on the crystal structure of GLP with H3K9me peptide (magenta) and SAH (yellow). d Unnatural lysine analogs possessing functionalities with a different nucleophilic character

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