Fig. 6: The interactions between Y658 and HRC residues.

a The contact probability between the hydrophobic residues in HRC with the Y658 (on KIX) in the encounter complex (state E), the hidden state (state H), intermediates (states I1 and I2), the transition state (state T) and the bound state (state B). b The representative structure of state H of pKID and KIX binding.