Fig. 7: Structure–kinetic activity effect of flavone compounds based on distribution of hydroxyl groups. | Communications Chemistry

Fig. 7: Structure–kinetic activity effect of flavone compounds based on distribution of hydroxyl groups.

From: Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

Fig. 7

Compounds are plotted according to their ability to reduce oligomer flux peak height (x-axis) and area (y-axis). Apigenin (bottom left region of the plot) confers the greatest potency. These findings suggest that the positioning of hydroxyl groups is important for determining the potency of flavone derivatives. More specifically, we define a ‘fingerprint’ for this positioning in terms of the number of hydroxyl groups on the left-hand side, central region and right-hand side (regions denoted in figure inset), respectively, finding that the (2,0,1) fingerprint of apigenin is the most effective one.

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