Fig. 3: Photoredox Trp and His modifications, and related mechanistic studies.
From: Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input
a Photochemical C–H perfluoroalkylation for labeling tryptophan, reported by Chen in 2017 (ref. 44). b Photoredox trifluoromethylation of tyrosine, reported by Lei and Chiang in 2019 (ref. 45). c Photoredox tryptophan bioconjugation with at the β-position of tryptophan, reported by Shi in 2018 (ref. 49). d Photochemical process for the selective modification of tryptophan residues with pyridinium salt, reported by Taylor in 2020 (ref. 47). e Photochemical trifluoromethylation of histidine, reported by Cohen in 1990 (ref. 53). f Histidine-specific peptide/protein modification via photoredox C–H alkylation reaction, reported by Wang and Chen in 2019 (ref. 54).
