Fig. 2: Substrate scope of carbamic chlorides.
From: Nickel-catalyzed enantioselective reductive carbo-acylation of alkenes
Reactions were performed on a 0.2 mmol scale of the carbamoyl chlorides 1a-p using 2.0 equiv of n-pentyl iodide (2a), 20 mol% NiBr2·glyme, 20 mol% racemic Pyrox L1 as ligand, and 2.0 equiv of Mn as reductant in DMA/NMM (4:1, 1.5 mL) at 0 °C. Reaction time: 24 h for 3aa-ea, 3ga, 3ja, and 3la; 48 h for 3 ha, 3ia, 3ka, 3ma, and 3na; and 96 h for 3fa, 3oa, and 3pa. aReaction was performed on 1-mmol-scale.
