Fig. 4: Enantioselective Ni-catalyzed carbo-acylation.
From: Nickel-catalyzed enantioselective reductive carbo-acylation of alkenes
Unless otherwise specified, reactions were performed on a 0.2 mmol scale of carbamoyl chlorides 1 using 2.0 equiv of alkyl iodides 2, 20 mol% NiBr2·glyme, 20 mol% Pyrox L12 as ligand, and 2.0 equiv of Mn as reductant in DMA/NMM (4:1, 1.5 mL) at 10 °C for 48 h. Enantiomeric excessess were determined by HPLC analysis on chiral stationary phase. aReaction was performed on 1-mmol-scale. bReaction time: 96 h. cReaction was performed at room temperature. dReaction time: 24 h. eBenzyl chloride was used.
