Fig. 7: Synthesis of compound 1.

Reagents and conditions: i DMF, K₂CO₃, 120 °C, 12 h, 44%; ii H₂, Pd(OH)₂, 1,4-dioxane, 50 °C, 12 h, 92 %; iii I₂, PhI(OCOCF₃)₂, CH₂Cl₂, 20 °C, 12 h, 33 %³⁸; iv Pd(PPh₃)₄, CuI, Et₃N, 100 °C, 6 h, 95 %; v- PPTS, MeOH, THF, 50 °C, 12 h, 70%.