Fig. 5: Homology model of the tetrameric complex. | Communications Chemistry

Fig. 5: Homology model of the tetrameric complex.

From: A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state

Fig. 5: Homology model of the tetrameric complex.

The CTLD part is based on the co-crystal structure of the BI-0115-LOX-1 complex, whereas the neck domain is modeled based on the Homer coiled-coil domain PDB ID 3CVE. The grey bar at the bottom represents the membrane. One dimer is built up by one molecule colored in red and the second molecule in salmon, the second dimer by one blue and one light blue molecule. CTLD: C-type lectin-like domain.

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