Fig. 5: Cellular uptake of BSO-OxOAc as compared to free oxaliplatin and impact of acquired oxaliplatin resistance. | Communications Chemistry

Fig. 5: Cellular uptake of BSO-OxOAc as compared to free oxaliplatin and impact of acquired oxaliplatin resistance.

From: A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance

Fig. 5

a Parental HCT116 and oxaliplatin-resistant HCT116/OxR cells were exposed to the indicated concentrations of BSO-OxOAc and oxaliplatin for 3 h and cellular uptake quantified by ICP-MS. Data are depicted as mean ± SD. b Log-fold difference in the platinum accumulation between parental HCT116 and HCT116/OxR calculated from the data shown in (a). Statistical significance was tested using one-way ANOVA. *p < 0.05; ***p < 0.001.

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