Table 1 Significant Raman peaks observed in PC loadings contributing to the separation between SARS-CoV-2 and MeV-infected Vero E6 cells24,25,26,33,53,60.

From: Specific intracellular signature of SARS-CoV-2 infection using confocal Raman microscopy

Raman peaks in cm−1

Cytoplasm

Golgi-mitochondria-

Nucleus

MeV

SARS-CoV-2

MeV

SARS-CoV-2

MeV

SARS-CoV-2

586 (sym str PO34)

459 (DNA/Glycogen)

1258 (Ade/Cyt)

566 (Trp/Cyt/Gua)

733 (Ade)

566 (Cyt/Gua)

815 (Tyr)

566 (Trp/Cyt/Gua/Kyn)

1470 (lipids)

619 (Cys)

1011 (Str C-O Ribose)

675 (Gua)

1099 (str C-N)

749 (Trp)

1592 (Str C = C and C = N protein)

749 (Trp)

1258 (Ade/Cyt)

749 (Tyr)

1250 (Gua/Cyt)

842 (Trp/Kyn)

1661 (α-helix protein)

1125 (Trp/Str C-C lipids)

1279 (Nucleic acids/Phosphates)

839 (Pro/hydroxyproline, Tyr/glycogen)

1315 (Gua)

1125(Str C-C lipids/glucose/polysaccharide)

2935 (CH3 sym str proteins)

1429 (Deoxyribose)

1289 (Cyt)

931 (Gua)

1487 (Gua)

1201 (Trp)

 

1732 (lipids)

1345 (Gua)

1125* C-O ribose

1575 (Gua/Ade)

1429 (Fatty acids)

 

2847 (CH3 sym str lipids)

1470* (lipids)

1235*PO2 mode

1629 (Tyr)

1510 (Cyt)

  

1641* (proteins)

1378 (Ade/Gua)

1661 (α-helix protein)

1547 (Trp)

  

1686* (proteins)

1429 (Deoxyribose)

2939 (lipids)

1607 (Trp)

  

2935* (proteins)

1477 (Gua)

 

1732 (lipids)

  

2970* (lipids)

1575 (Gua/Ade)

 

2849 (CH3 sym str lipids)

   

1732* (lipids)

 

3026 (long-chain fatty acid)

   

2864* (lipids)

     

3026 (long-chain fatty acid)

  1. Trp tryptophan, Cys cysteine, Tyr tyrosine, Cyt cytosine, Gua guanine, Pro proline, Sym symmetric, Str stretching, Ade adenine, Kyn kynurenine.
  2. *The contribution of these Raman bands arises due to the extraction of nucleic acid spectra from the Raman spectroscopic image of the cells.