Fig. 5: Perfluoroaryl-stapled and alanine-substituted peptides demonstrate high-affinity binding. | Communications Chemistry

Fig. 5: Perfluoroaryl-stapled and alanine-substituted peptides demonstrate high-affinity binding.

From: Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions

Fig. 5: Perfluoroaryl-stapled and alanine-substituted peptides demonstrate high-affinity binding.

a Perfluoroaryl-stapled and alanine-substituted peptides 35–40 with low nanomolar binding affinity were generated at tolerable (i, i + 4) stapling sites (Fig. 3c). b Structure of peptide 39, alanine is colored in purple and stapling sites are colored in blue. c Example competition binding curves of peptides. C* = cysteine stapled with hexafluorobenzene.

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