Fig. 3: Iterative synthesis of spirocyclic foldamers. | Communications Chemistry

Fig. 3: Iterative synthesis of spirocyclic foldamers.

From: A spirocyclic backbone accesses new conformational space in an extended, dipole-stabilized foldamer

Fig. 3: Iterative synthesis of spirocyclic foldamers.The alternative text for this image may have been generated using AI.

a 6 (1-1.2 equiv.), Pd2(dba)3 (10 mol%), Xantphos (30 mol%), Cs2CO3 (2.5 equiv.), PhMe, 80 °C; b TfOH (5-9 equiv.), DCE, 80 °C, 8 h; c 2,5-dibromopyrazine (0.5 equiv.), Pd2(dba)3 (10 mol%), Xantphos (30 mol%), Cs2CO3 (2.5 equiv.), PhMe, 80 °C, 2 h, 60% yield. Supplementary Data 2 and CCDC 2170496 contain the single crystal data for 7. TfOH trifluoromethanesulfonic acid, DCE 1,2-dichloroethane; dba dibenzylidineacetone.

Back to article page