Fig. 4: Analysis of ROESY spectral data for control compounds 14 and 15 (CDCl3, tmix 0.2 s). | Communications Chemistry

Fig. 4: Analysis of ROESY spectral data for control compounds 14 and 15 (CDCl3, tmix 0.2 s).

From: A spirocyclic backbone accesses new conformational space in an extended, dipole-stabilized foldamer

Fig. 4: Analysis of ROESY spectral data for control compounds 14 and 15 (CDCl3, tmix 0.2 s).The alternative text for this image may have been generated using AI.

Rotating Frame Overhauser Enhancement Spectroscopy (ROESY) cross-peak intensities are indicated, and normalised relative to the geminal enhancement (in green). anti: syn ratios about each C-N bond are approximated by the formula provided in the inset. This assumes that where cross-peaks are to a pair of diastereotopic methylene hydrogens the average of these intensities is given. a 4-Bromopyridine hydrochloride (1.5 equiv.), Pd2(dba)3 (10 mol%), Xantphos (30 mol%), Cs2CO3 (3.6 equiv.), PhMe, 80 °C, 14: 4 h reaction, 75% yield, 15: 3 h reaction, 58% yield; b the average value of the nOe enhancements to both diastereotopic hydrogens is given; c cross-peaks overlap.

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