Fig. 4: Analysis of ROESY spectral data for control compounds 14 and 15 (CDCl3, tmix 0.2 s). | Communications Chemistry

Fig. 4: Analysis of ROESY spectral data for control compounds 14 and 15 (CDCl3, tmix 0.2 s).

From: A spirocyclic backbone accesses new conformational space in an extended, dipole-stabilized foldamer

Fig. 4

Rotating Frame Overhauser Enhancement Spectroscopy (ROESY) cross-peak intensities are indicated, and normalised relative to the geminal enhancement (in green). anti: syn ratios about each C-N bond are approximated by the formula provided in the inset. This assumes that where cross-peaks are to a pair of diastereotopic methylene hydrogens the average of these intensities is given. a 4-Bromopyridine hydrochloride (1.5 equiv.), Pd2(dba)3 (10 mol%), Xantphos (30 mol%), Cs2CO3 (3.6 equiv.), PhMe, 80 °C, 14: 4 h reaction, 75% yield, 15: 3 h reaction, 58% yield; b the average value of the nOe enhancements to both diastereotopic hydrogens is given; c cross-peaks overlap.

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