Fig. 6: The turnover rates of histones are accurately computed by the approach using two mass isotopomers. | Communications Chemistry

Fig. 6: The turnover rates of histones are accurately computed by the approach using two mass isotopomers.

From: Quantifying label enrichment from two mass isotopomers increases proteome coverage for in vivo protein turnover using heavy water metabolic labeling

Fig. 6

Slow turnover rates of Histones are reflected in the time series of label incorporation obtained using complete (experimental) isotope profiles and reconstructed isotope profiles (using a pair of mass isotopomers). Shown are the labeling time series data of a peptide of histones: (a) H2A1B (histone 2A type 1-B), (b) H2B1B (histone 2B type 1-B), (c) H3.2 (histone H3.2), (d) H4 (histone H4), (e) H1.4 (histone H1.4), and (f) H2AY (core histone macro-H2A.1).

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