Fig. 7: Interactions in the representative structures (most abundant cluster) of NNRTIs and HIV-1 RT. | Communications Chemistry

Fig. 7: Interactions in the representative structures (most abundant cluster) of NNRTIs and HIV-1 RT.

From: Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

Fig. 7: Interactions in the representative structures (most abundant cluster) of NNRTIs and HIV-1 RT.The alt text for this image may have been generated using AI.

a K103N-18b1, b K103N-ETR, c E138K-18b1, d E138-ETR, e V106A/F227L-18b1 and f V106A/F227L-ETR. Mutated amino acids are presented inside a box. Amino acids that are not involved in interactions with ETR are represented in lines. Inhibitor is represented as balls and sticks.

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