Fig. 3: Substrate scope of the MBH carbonates and enynamidesa. | Communications Chemistry

Fig. 3: Substrate scope of the MBH carbonates and enynamidesa.

From: Silver/chiral pyrrolidinopyridine relay catalytic cycloisomerization/(2 + 3) cycloadditions of enynamides to asymmetrically synthesize bispirocyclopentenes as PDE1B inhibitors

Fig. 3

aConditions: 1 (0.1 mmol) and AgOAc (10 mol%) in CHCl3 (1.0 mL) was stirred at 40 °C for 1 h. Then, 2 (0.1 mmol) and C9 (20 mol%) were added, and the reaction was stirred at 0 °C for 48 h and at 40 °C for another 3 h.

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