Fig. 3: Substrate scope of alkane radical source. | Communications Chemistry

Fig. 3: Substrate scope of alkane radical source.

From: Acceptorless cross-dehydrogenative coupling for C(sp3)-H heteroarylation mediated by a heterogeneous GaN/ketone photocatalyst/photosensitizer system

Fig. 3

Reaction conditions: 1a (0.1 mmol). 2 (0.125 M for liquids or 3.5 equiv for solids), 1 wt% Rh2O3/GaN (15 mol%), benzophenone (15 mol%), TFA (2 equiv), CH3CN (0.2 mL for liquid alkane or 0.8 mL for solid alkane source), and PhH (0.1 mL for liquid alkane or 0.3 mL for solid alkane source) under the Kessil lamp light source (390 nm) for 20 h under Ar atmosphere at 35 °C. Isolated yields are reported unless otherwise noted. Reaction conditions for gram-scale reaction: 1a (4.9 mmol). 2 g (15 mmol), 1 wt% Rh2O3/GaN (30 mol%), benzophenone (30 mol%), TFA (4 equiv), CH3CN (10 mL), and PhH (3 mL) under the Kessil lamp light source (390 nm) for 72 h under Ar atmosphere at 35 °C. aPhH (0.4 mL) and 28 h reaction time. TFA trifluoroacetic acid, 2-Me-THF 2-methyltetrahydrofuran, THP tetrahydropyran.

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