Fig. 2: SARS-CoV-2 Mpro hits, analogs synthesized off-DNA. Numbers indicate Ki values determined as described in methods.

Inactive: compounds that inhibited Mpro activity by less than 90% with 25 μM. Yellow background; Mpro inhibitors that are enriched in DEL selections. Green background; Mpro inhibitors that are analogs synthesized based on DEL hits.