Fig. 2: Nitric oxide and calcium in endothelial cells in healthy and disease setting.
From: Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction
a The cell signalling pathway from intracellular Ca2+ to nitric oxide in homoeostatic endothelial cell, and b in a stressed endothelial cell. c, d NO release from single endothelial cell after stimulation with Calcium Ionophore A23187 (CaI) in vitro from iliac artery of c normotensive rat and d hypotensive rat51 as measured with a single fibre porphyrinic sensor. e–g Calcium signalling pattern in endothelial cells under resting conditions (Reprinted with permission from ref. 51). e X–Y image of single endothelial cells showing calcium oscillations in sites 1 and 2 (marked). f Calcium concentration vs. time at the site 1. g Calcium concentration vs. time at the site 252 (Reprinted with permission from Elsevier (Burdyga et al.52, Copyright 2003)).
