Table 2 Calcium sensors discussed in this review.
From: Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction
Number | Name | Kd, µM | Selectivity to Ca2+ against Mg2+, Zn2+ and Na+ | λem, nm | pH | Stability in cell environment | Turn-on sensor (ON)/Turn-off (OFF) | Ref. |
|---|---|---|---|---|---|---|---|---|
18 | BAPTA sensor family | 0.15; ~0.70a | Selective | Fluorophore dependent | Cytosolicd | Stable | ON | |
19 | – | 256b | Selective | 488 | – | – | ON | |
20 | BCaM | 90 | Selective | 450 | Cytosolicd | Stable | ON | |
21 | Bichromophore | 14.8 | Selective | 436 | – | – | ON | |
22 | Calix[4]arene | 121b | Selective | 510 | – | – | ON | |
23 | – | 2400 | Selective | 550 | 8.1 | – | ON | |
24 | PIAQ–AC 5a | 0.309b | Not selective | 515 | – | – | ON | |
25 | PIAQ–AC 5b | 0.069b | Not selective | 515 | – | – | ON | |
26 | – | 0.0192 | 485c | – | – | |||
27 | DMK | 0.0144 | Selective | 390 | 4 | – | ON | |
28 | ISB | LOD = 0.3 | Selective | 483 | 7.2 | – | ON | |
29 | MPFCP-1 | 0.44 | Selective | 525 | Cytosolicd | Stable | ON | |
30 | MPFCP-2 | 1.21 | Selective | 525 | Cytosolicd | Stable | ON | |
31 | BODIPY-BAPTA | 0.501b | Selective | 508 | 7.2 | Stable | ON | |
32 | JF549-BAPTA | 0.31 | Selective | 569 | Cytosolicd | Stable | ON | |
33 | CaSIR-1 | 0.58 | Selective | >650 | Cytosolicd | Stable | ON | |
34 | – | 5120 | Selective | 655 | – | – | OFF | |
35 | Di-Aza-crown-cNDI | 0.11b | Selective against Mg2+ and Na+ | 655 | – | – | ON | |
36 | CaRB | 1.22 | Selective | 631 | 7.2 | 7.2 | ON | |
37 | Calix[4]arene-BDP | – | Selective against Mg2+ | 507 | – | – | OFF |