Fig. 6: Biopharmaceutical properties of crystalline CEL and its amorphous formulations, showing the best performance for the CEL-PVP-VA salts. | Communications Chemistry

Fig. 6: Biopharmaceutical properties of crystalline CEL and its amorphous formulations, showing the best performance for the CEL-PVP-VA salts.

From: Comparative analysis of drug-salt-polymer interactions by experiment and molecular simulation improves biopharmaceutical performance

Fig. 6

a Apparent solubility in aqueous medium (water) for 6 h. b Dissolution profile under non-sink and sink conditions in pH 11 and 12 buffer media, respectively, for 2 h as per OGD recommendation for dissolution performance. Measurements for a and b were made in triplicate. c Plasma concentration vs time profile from pharmacokinetic studies performed for 48 h in SD female rats (n = 5). All data for this figure are provided in Supplementary Data 2.

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